Frontline Plus for Large Dogs (45-88 lbs) Purple Box

Monthly Topical Flea & Tick Spot Treatment

Product Description

Frontline Plus for Large Dogs provides fast-acting, long-lasting protection against fleas, ticks, and chewing lice through waterproof topical application. This dual-action formula combines fipronil and (S)-methoprene to kill adult fleas, eggs, larvae, and all tick life stages while preventing re-infestation for 30 days on dogs 8 weeks or older weighing 45-88 lbs.

Ingredients

Active Ingredients

Fipronil 9.8%, (S)-methoprene 8.8%

Inactive Ingredients

Butylhydroxytoluene, dipropylene glycol monomethyl ether, fractionated coconut oil, other ingredients

Variants/Types

How to Use

Dosage & Administration Instructions

• Weight Confirmation: Verify the dog weighs between 45 and 88 lbs for the purple box formulation.
• Applicator Preparation: Snap tip away from body, hold upright to prevent spilling.
• Application Site: Part fur between the shoulder blades until skin is visible beneath.
• Single Spot: Squeeze entire contents directly onto skin in one location only.
• Drying Time: Allow 24 hours before bathing or swimming for waterproof protection.

Additional Information

Precautions

• Age Restriction: Use only on dogs and puppies 8 weeks or older.
• Species Warning: Do not use on cats; keep treated dogs away from cats until dry.
• Skin Contact: Avoid touching the application site until completely dry; wash hands after use.
• Child Safety: Prevent children from playing with treated animals until the application site dries.
• Water Activities: Wait 24 hours after application before bathing or allowing swimming.

Possible Side Effects

• Skin Irritation: Temporary redness, scratching, or discomfort may occur at the application site.
• Hair Changes: Localized hair loss, stiffness, or discoloration may be temporarily possible.
• General Reactions: Rare systemic itching or hair loss reported in sensitive dogs.
• Ingestion Effects: Drooling, nausea, or vomiting if the product is licked accidentally.
• Application Sensitivity: Excessive salivation may occur if the dog contacts the treated area.

Benefits

• Dual Action: Kills adult fleas and prevents all flea life stages from developing.
• Tick Protection: Eliminates deer, brown dog, American dog, and Lone Star ticks effectively.
• Disease Prevention: Kills ticks that may transmit Lyme disease and Rocky Mountain spotted fever.
• Waterproof Formula: Maintains effectiveness after bathing, swimming, or rain exposure for 24 hours.
• Long-Lasting: A single application provides continuous protection for 30 days against reinfestation.

Shipping & Return

We offer ground, express, priority, and international delivery; see our shipping policy for details.

For return instructions or product concerns, please refer to our detailed refund policy.

Frequently Asked Questions

Q1: How quickly does Frontline Plus start killing fleas and ticks after application?

Ans: Frontline Plus begins killing adult fleas within 12 hours and ticks within 48 hours of application. The fipronil ingredient collects in skin oils and hair follicles, providing continuous parasite elimination throughout the full 30-day protection period for sustained effectiveness.

Q2: Can my dog swim or bathe after applying Frontline Plus?

Ans: Yes, Frontline Plus becomes waterproof 24 hours after application. Once this drying period passes, your dog can swim, bathe, or be exposed to rain without reducing the product's effectiveness for the remaining protection period.

Q3: Is Frontline Plus safe for puppies, and what is the minimum age requirement?

Ans: Frontline Plus is safe for puppies 8 weeks of age and older weighing at least 5 pounds. Always choose the correct weight-based formulation and consult your veterinarian before treating very young, sick, or medicated puppies.

Q4: What should I do if my dog shows skin irritation at the application site?

Ans: Mild skin irritation is normal and typically resolves within a few days. If redness, scratching, or discomfort persists beyond three days or becomes severe, wash the area with mild soap and contact your veterinarian immediately.

Q5: Why do I see more fleas after treating my dog with Frontline Plus?

Ans: Increased flea visibility is normal as dying fleas rise to the coat surface and become more active before death. Environmental fleas may continue jumping on your dog for up to 90 days until the complete flea lifecycle is broken.